MateriAlZ Seminar: Shaochen Chen
Friday, October 20th, 2023 - 11 a.m.
Shaochen Chen
Zable Endowed Chair Professor, NanoEngineering Department
Professor, Bioengineering Department
University of California, San Diego
"Rapid 3D Bioprinting of Engineered Tissues with Digital Control of Material Properties"
Zoom link | Passcode 713581
MateriAlZ Seminar website | YouTube | Twitter
Abstract
In this talk, I will present our laboratory’s recent research efforts in developing rapid, digital light processing (DLP) based bioprinting methods to create 3D tissue constructs using a variety of biomaterials and cells. These 3D printed scaffolds are functionalized with precise control of micro-architecture, mechanical (e.g. stiffness), chemical, and biological properties. Such functional scaffolds allow us to investigate microscale cell-microenvironment interactions in response to integrated mechanical and chemical stimuli. From these fundamental studies we have been creating both in vitro and in vivo precision tissues for tissue regeneration, disease modeling, and drug discovery. Examples including 3D bioprinted liver and heart models will be discussed. I will also showcase 3D printed biomimetic scaffolds for treating spinal cord injury. Throughout the presentation, I will discuss engineer’s perspectives in terms of design innovation, biomaterials, mechanics, and scalable biomanufacturing.
References
[1] You et al, “High Cell Density and High Resolution 3D Bioprinting for Fabricating Vascularized Tissues”, Science Advances, 9 (no. 8), eade7923, 2023.
[2] Koffler et al., “Biomimetic 3D-Printed Scaffolds for Spinal Cord Injury”, Nature Medicine, 25, 263-269, 2019.
[3] Ma et al., Deterministically Patterned Biomimetic Human iPSC-derived Hepatic Model via Rapid 3D Bioprinting”, PNAS, 113 (no. 8), pp. 2206-2211, 2016.
Bio
Dr. Shaochen Chen is Zable Endowed Chair Professor in the NanoEngineering Department and Professor in the Bioengineering Department at the University of California, San Diego (UCSD). He is the founding director of the Biomaterials and Tissue Engineering Center at UCSD. Before joining UCSD, Dr. Chen had been a professor and a Henderson Centennial Endowed Faculty Fellow in engineering at the University of Texas at Austin from 2001 to 2010. Between 2008 and 2010, he served as the program director for nanomanufacturing at NSF. Dr. Chen’s primary research interests include: 3D printing and bioprinting, biomaterials and nanomaterials, stem cell and regenerative medicine, and tissue engineering. He has published over 170 papers in top journals. Among his numerous awards, Dr. Chen received the NSF CAREER award, ONR Young Investigator award, and NIH Edward Nagy New Investigator Award. For his seminal work in 3D printing and bioprinting, he received the Milton C. Shaw Manufacturing Research Medal from the American Society of Mechanical Engineers (ASME) in 2017 and Frederick W. Taylor Research Medal from the Society of Manufacturing Engineers in 2023. Dr. Chen is an elected fellow of the US National Academy of Inventors and a member of the European Academy of Sciences and Arts, a Fellow of AAAS, AIMBE, ASME, & SPIE. In 2022, Dr. Chen was awarded as a BRITE Fellow of NSF to advance 3D biomanufacturing techniques.