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Arizona Health Sciences Center 201
John A. Szivek
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Professor of Orthopaedic Surgery
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Professor of Biomedical Engineering
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Professor, Physiological Sciences Graduate Interdisciplinary Program
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Professor, BIO5 Institute
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Adjunct Associate Professor of Materials Science and Engineering
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Adjunct Associate Professor of Aerospace and Mechanical Engineering
Biographical Sketch for John A. Szivek, Ph.D.
Dr. Szivek was educated in Toronto, Canada where he completed his PhD. His research topic was a study of the nature of activity induced bone formation and the study of bone loss around orthopedic implants.
Dr. Szivek moved to the University of Arizona in the fall of 1990 where he was appointed to direct the Orthopedic Research Laboratory, in the Department of Surgery at the College of Medicine. He is a senior researcher in the Arizona Arthritis Center and in 2003 was awarded the William and Sylvia Rubin Chair in Orthopaedic Research by the Department of Orthopaedic Surgery to support his studies on cartilage regeneration and in vivo load sensing. The Center has scientists from a number of disciplines working together at the University of Arizona to develop better treatment for persons suffering from arthritis. Dr. Szivek has had a number of federal and private grants to study the effect of exercise on bone and cartilage and to measure loads acting on healthy musculoskeletal tissues to better understand osteoarthritis and potential treatments for patients with osteoarthritis.
Degrees
- Post-Doctoral Fellowship
- University of Toronto, Toronto, CA
- Ph.D.
- University of Toronto, Toronto, CA
- Master of Applied Science
- University of Toronto, Toronto, CA
- Bachelor of Applied Science - Cum Laude
- University of Toronto, Toronto, CA
Work Experience
- Biomedical Engineering Graduate Interdisciplinary Program (2011 - 2015)
- University of Arizona, Tucson (2010 - 2015)
- University of Arizona, Tucson (2006 - Ongoing)
- University of Arizona, Tucson, Arizona (2006 - Ongoing)
- University of Arizona, Tucson (2003 - 2019)
- University of Arizona, Tucson (1998 - 2006)
- University of Arizona, Tucson (1996 - 2016)
- University of Arizona, Tucson (1996 - 1998)
- University of Arizona, Tucson (1994 - Ongoing)
- University of Arizona, Tucson (1993 - Ongoing)
- University of Arizona, Tucson (1990 - Ongoing)
- University of Arizona, Tucson (1990 - 2019)
- University of Arizona, Tucson (1990 - 1995)
- Harrington Arthritis Research Center (1989 - 1990)
- Arizona State University (1985 - 1990)
- Arizona State University, Phoenix, Arizona (1985 - 1990)
- Maricopa County Residency Program (1985 - 1990)
- Harrington Arthritis Research Center (1985 - 1989)
Interests
Teaching
Bioengineering - Orthopaedic Biomaterials and Biomechanics -Orthopaedic Tissue Engineering - 3D Printing of Scaffolds and Cell Extraction and Utilization in Tissue Engineering - Implantable load sensor and Telemetry development
Research
Orthopaedic Biomaterials and Biomechanics -3D printing - Free Form Fabrication - Additive manufacturing -Pluripotent cell extraction, differentiation and utilization in tissue engineering -In vivo sensor and telemetry development for load measurement
Courses
Independent Study
MCB 199 (Fall 2021)
Directed Research
BME 492 (Spring 2018)
BME 492 (Fall 2017)
PCOL 392 (Fall 2019)
Honors Independent Study
BIOC 399H (Spring 2020)
MCB 499H (Spring 2018)
MCB 499H (Fall 2017)
PSIO 499H (Spring 2017)
Biomechanical Engr
AME 466 (Fall 2016)
AME 566 (Fall 2016)
BME 466 (Fall 2016)
BME 566 (Fall 2016)
Honors Directed Research
BIOC 492H (Fall 2020)
BIOC 492H (Fall 2019)
Senior Capstone
BIOC 498 (Spring 2022)
BIOC 498 (Fall 2021)
Honors Thesis
BIOC 498H (Spring 2021)
BIOC 498H (Fall 2020)
Rsrch Meth Biomed Engr
BME 597G (Fall 2017)
Research
PS 900 (Spring 2016)
Selected Publications
Chapters
- Szivek, J. A. (2008). Resorbable Polymer-Ceramic Composites for Orthopedic Scaffold Applications. In 28th International Conference on Advanced Ceramics and Composites B: Ceramic Engineering and Science Proceedings, Volume 25, Issue 4.
- Szivek, J. A., Vaidyanathan, R., Hecht, B., Studley, A., Phillips, T., Calvert, P. D., Tellis, B., & Coleman, A. (2008). Resorbable Polymer‐Ceramic Composites for Orthopedic Scaffold Applications. In 28th International Conference on Advanced Ceramics and Composites B: Ceramic Engineering and Science(pp 529-536). doi:DOI:10.1002/9780470291191.ch80
- Szivek, J. A. (1999). Synthetic Materials and Structures Used as Models for Bone. In Mechanical Testing of Bone and the Bone-Implant Interface(pp 159-171).
- Szivek, J. A. (1999). Synthetic materials and structures used as models for bone. In Mechanical Testing of Bone and the Bone-Implant Interface(pp 159-171). CRC Press.
- Szivek, J. A., & Gharpuray, V. M. (1999). Strain Gauge Measurements from Bone Surfaces. In Mechanical Testing of Bone and the Bone-Implant Interface(pp 305-320).
Journals/Publications
- Szivek, J. A., & Karl, W. H. (2021). Repair and remodeling of partial-weightbearing, uninstrumented long bone fracture model in mice treated with low intensisty vibration therapy. Clinical Biomechanics, 81.
- Szivek, J. A. (2019). A Purification Technique for Adipose-Derived Stromal Cell Cultures Leads to a More Regenerative Cell Population. Journal of Investigative Surgery.
- Szivek, J. A. (2019). Mesenchymal stem cell seeded, biomimetic 3D printed scaffolds induce complete bridging of femoral critical sized defects. Journal of Biomedical Materials Research Part B: Applied Biomaterials.
- Conway, R. F., Okarski, K. M., & Szivek, J. A. (2018). A Purification Technique for Adipose-Derived Stromal Cell Cultures Leads to a More Regenerative Cell Population. J Investigative Surgery. doi:DOI:10.1080/08941939.2017.1423420
- Szivek, J. A., Gonzales, D. A., Wojtanowski, A. M., Martinez, M. A., & Smith, J. L. (2018). Mesenchymal stem cell seeded, biomimetic 3D printed scaffolds induce complete bridging of femoral critical sized defects. Journal of biomedical materials research. Part B, Applied biomaterials.
- Szivek, J. A. (2017). Determination of joint loads using new sensate scaffolds for regenerating large cartilage defects in the knee. Journal of Biomedical Materials Research Part B: Applied Biomaterials.
- Szivek, J. A., Ruth, J. T., Heden, G. J., Martinez, M. A., Diggins, N. H., & Wenger, K. H. (2017). Determination of joint loads using new sensate scaffolds for regenerating large cartilage defects in the knee. Journal of biomedical materials research. Part B, Applied biomaterials, 105(6), 1409-1421.
- Ferng, A. S., Marsh, K. M., Fleming, J. M., Conway, R. F., Schipper, D., Bajaj, N., Connell, A. M., Pilikian, T., Johnson, K., Runyan, R., Black, S. M., Szivek, J. A., & Khalpey, Z. (2016). Adipose-derived human stem/stromal cells: comparative organ specific mitochondrial bioenergy profiles. SPRINGERPLUS, 5.
- Gao, L., Schmitz, H. A., Zuniga, A. A., Klewer, J. A., Szivek, J. A., Taljanovic, M. S., Latt, L. D., & Witte, R. S. (2016). Minimizing strain error for in vivo ultra-sound elasticity imaging of human tendon. 2016 IEEE INTERNATIONAL ULTRASONICS SYMPOSIUM (IUS).
- Szivek, J. A. (2016). Adipose-derived human stem/stromal cells: comparative organ specific mitochondrial bioenergy profiles. SpringerPlus.
- Gao, L., Yuan, J. S., Heden, G. J., Szivek, J. A., Taljanovic, M. S., Latt, L. D., & Witte, R. S. (2015). Ultrasound Elasticity Imaging for Determining the Mechanical Properties of Human Posterior Tibial Tendon: A Cadaveric Study. IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING, 62(4), 1179-1184.
- Szivek, J. A. (2015). Ultrasound Elasticity Imaging for Determining the Mechanical Properties of Human Posterior Tibial Tendon: A Cadaveric Study. IEEE Transactions on Biomedical Engineering.
- Szivek, J. A. (2014). In vivo telemetric determination of shear and axial loads on a regenerative cartilage scaffold following ligament disruption. Journal of Biomedical Materials Research Part B: Applied Biomaterials.
- Szivek, J. A. (2013). Co-culture of adipose derived stem cells and chondrocytes with surface modifying proteins induces enhanced cartilage tissue formation. Journal of Investigative Surgery.
- Waters, H. A., Geffre, C. P., Gonzales, D. A., Grana, W. A., & Szivek, J. A. (2013). Co-Culture of Adipose Derived Stem Cells and Chondrocytes with Surface Modifying Proteins Induces Enhanced Cartilage Tissue Formation. Journal of Investigative Surgery, 26(3), 118-126.
Proceedings Publications
- Figueroa, G., Gonzales, D. A., Viiialobos, E. B., Arciniaga, L. F., Loy, D. A., Muralidharan, K., Potter, B. G., Szivek, J. A., & Margolis, D. S. (2021, April). Resorbable Composite Polymer Ceramic Scaffolds Support Bone Growth and Bonding In Vivo. In Society for Biomaterials, Virtual Meeting.
- Szivek, J. A., Arciniaga, L. F., Rajendran, V., Loy, D. A., Barron Villalobos, E., Gonzales, D. A., & Margolis, D. S. (2020, February). Osteoconductive Biomimetic Polymer Ceramic Bone Scaffolds. In Orthopedic Research Society, Phoenix Arizona February 2020.
- Szivek, J. A., Margolis, D. S., Gonzales, D. A., Barron Villalobos, E., Gutruf, P., Peralta, R. W., & Cai, L. (2020, August). Direct Measurement of In Vivo Bone Strain with Implantable Wireless Battery Free Devices. In Dept of Defence, Military Health Conf, MHSRS, Kissimmee FL, August 2020.
- Szivek, J. A., Margolis, D. S., Barron Villalobos, E., Arciniaga, L. F., Rajendran, V., Gonzales, D. A., & Loy, D. A. (2020, February). Resorbable Polymer Ceramic Composite Biomimetic Scaffolds Support Osteoblastic Differentiation of Stem Cells. In Orthopedic Research Society, Phoenix Arizona February 2020.
- Szivek, J. A., Margolis, D. S., Gonzales, D. A., & Barron Villalobos, E. (2020, August). Can Direct Loading Measurements Define the Extent of Healing in Sensate Long Bone Segment Regeneration Scaffolds. In Dept of Defence, Military Health Conf, MHSRS, Kissimmee FL, August 2020.
- Szivek, J. A. (2019). Stem cells are necessary to bridge a critical size gap when a biomimetic scaffold is used to regenerate a large segmental femoral defect. In Transactions of the Annual Meeting of the Society for Biomaterials and the Annual International Biomaterials Symposium.
- Szivek, J. A. (2018). Structural and functional assessment of intense therapeutic ultrasound effects on partial Achilles tendon transection. In Progress in Biomedical Optics and Imaging - Proceedings of SPIE.
- Szivek, J. A. (2017). A model for use in the prognosis of tendinopathy. In Simulation Series.
- Szivek, J. A. (2016). Minimizing strain error for in vivo ultra-sound elasticity imaging of human tendon. In IEEE International Ultrasonics Symposium, IUS.
- Szivek, J. A. (2016, December). Environmental Stress Increases Stem Cell Concentration In Extracted Stromal Cell Batches. In Tissue Engineering Part A.
- Szivek, J. A. (2008). In vivo bone strain measurements collected from mouse femora using CPC coated strain Gauges. In 8th World Biomaterials Congress 2008.
- Szivek, J. A. (2008). PBT scaffolds with a biomimetic trabecular porous architecture accelerates bone growth into scaffold pores. In 8th World Biomaterials Congress 2008.
- Szivek, J. A. (2008). Sensate PBT scaffolds measure changes in joint loading and drug efficacy following ACL transection to induce osteoarthrits. In 8th World Biomaterials Congress 2008.
- Szivek, J. A. (2004). Bone remodeling in CAII deficient and calbindin-D28k KO mice. In Transactions - 7th World Biomaterials Congress.
- Szivek, J. A. (2004). Determination of contact pressures in the canine stifle joint. In Transactions - 7th World Biomaterials Congress.
Poster Presentations
- Barron, E., Barreda, A., Gonzales, D. A., & Szivek, J. A. (2017, November). Infiltration path evaluation in human sized scaffolds for a segmental defect. Junior Investigator Poster Forum, University of Arizona. Tucson, AZ: University of Arizona.
- Gonzales, D. A., Wojtanowski, A. M., Kay, R. D., Margolis, D. S., Smith, J. L., & Szivek, J. A. (2017, November). Cell Infiltrated Scaffolds Induce Extensive Bone Growth in Critical Sized Defects. Junior Investigator Poster Forum, University of Arizona. Tucson, AZ: University of Arizona.
- Smith, J. L., Barreda, A., Gonzales, D. A., Wojtanowski, A. M., Buchak, J., Szivek, J. A., & Margolis, D. S. (2017, June). Development and Testing of a Long Bone Segment Regenerating Scaffold for Patients.. Summer Biomechanics, Bioengineering and Biotransport Conference. Tucson, Arizona: SB3C.
- Szivek, J. A., Gonzales, D. A., Kay, R. D., Margolis, D. S., & Smith, J. L. (2017, Summer). Cell-Free Biomimetic Scaffolds Lead to Non-Unions in Critical Sized Defect Repair as Compared to Identically Structured Stem Cell Infiltrated Scaffolds that Induce Rapid Bone Growth. Orthopaedic Research Society - Sun Valley Workshop. Sun Valley: Orthopaedic Research Society.
- Szivek, J. A., Walker, K., & Gonzales, D. A. (2017, November). Evaluation of a Cavitation-Based Extraction of Adipose Derived Stromal Cells for Clinical Testing. Junior Investigator Poster Forum, University of Arizona. Tucson, AZ: University of Arizona.
- Schmitz, H., Gao, L., Ingram, C. P., Klewer, J., Szivek, J. A., Taljanovic, M., Latt, D. L., & Witte, R. S. (2016, January). Ultrasound Elasticity Imaging of the Posterior Tibial Tendon using FOCUS Simulation Software. 27th Annual Undergraduate Biology Research Program Conference. Tucson, AZ.
Presentations
- Szivek, J. A., Margolis, D. S., & Larson, D. (2019, January). Patient Specific Scaffolds for Treatment of Scaphoid Fractures and Nonunions with Significant Bone Loss. American Association for Hand Surgery Annual Meeting. Palm Desert, CA: American Association for Hand Surgery.
- Szivek, J. A., Margolis, D. S., Gonzales, D. A., Barron, E., & Larson, D. (2019, September). Development of a Porcine Model to Treat Scaphoid Nonunion with 3D Printed Scaffolds. 7th Annual meeting of the ASSH. Las Vegas NV: ASSH.
- Barton, J. K., Rice, P. S., Howard, C., Koevary, J. W., Danforth, F., Gonzales, D. A., Vande Geest, J., Latt, D., Szivek, J. A., Amodei, R., & Slayton, M. (2018, January). Structural and functional assessment of intense therapeutic ultrasound effects on partial Achilles tendon transection. Advanced Biomedical and Clinical Diagnostic and Surgical Guidance Systems XVI, part of SPIE BiOS. San Francisco, CA: SPIE BiOS.
- Szivek, J. A., Buchak, J., & Smith, J. L. (2017, April). A Patient Specific 3D Printed Scaffold for Femoral Long Segment Regeneration. Annual Society for Biomaterials Meeting. Minneapolis, MN: Society for Biomaterials.
- Szivek, J. A., Buchak, J., Wotanowski, A. M., Gonzales, D. A., Barreda, A., Smith, J. L., & Margolis, D. S. (2017, June). Development and Biomechanical Testing of a Human Long Bone Segment Regenerating Scaffold. Summer Biomechancis, Bioengineering and Biotransport Conference (SB3C). Tucson, AZ.
- Latt, D. L., Gao, L., Taljanovic, M., Szivek, J. A., Guerra, J. D., Klewer, J. A., & Witte, R. S. (2016, March). In Vivo Ultrasound Elasticity Imaging Differentiates Healthy From Diseased Tendons. Orthopaedic Research Society 2016 Annual Meeting. Orlando, Florida.
- Szivek, J. A., Okarski, K. M., Curtis, H. J., & Powers, L. S. (2016, December). Environmental Stress Increases Stem Cell Concentration In Extracted Stromal Cell Batches. TERMIS - Published in Tissue Engineering Part A, Vol 22, S8-S8, ISSN 1937-3341, 2016. San Diego, California: TERMIS.
Others
- Szivek, J. A. (1984, September). A Quantitative Study of the Effect of Strain Redistribution on Bone Remodelling. Thesis.
Awards
- Faculty Mentor Honor Roll
- UA, Department of Surgery, Spring 1998
- Alberta Visiting Professor Research Award
- Alberta Heritage Foundation, University of CalgaryArthritis Center, Calgary, Alberta Canada, Summer I 1997
- Public Policy and Advocacy Committee of Arthritis Foundation (Arizona Chapter)
- Arthritis Foundation, Spring 1997
- Governor's Advisory Council on Arthritis and Musculoskeletal Diseases
- Office of the Governor of the State of Arizona,The Honorable Fife Symington, Spring 1996
- Outstanding Conference Prsentation, The Knee Society
- The Knee Society, Spring 1992
- Outstanding Publication of the Year, Journal of Investigative Surgery
- Journal of Investigative Surgery, Spring 1992
- Louis J Kettle Medical Student Mentoring Award
- UA, Medical Student Research Program, Fall 1991
- UBRP Outstanding Faculty Mentor Award
- UA, University Biology Research Program, Fall 1990
- Board of Visitors Award, Saint Lukes Hospital
- Saint Lukes Hospital, Phoenix Arizona, Spring 1988
- Ontario Graduate Scholarship
- Province of Ontario/ University of Toronto, Fall 1980
- University of Toronto Open Scholarship
- Graduate College, University of Toronto, Fall 1979
- Bronze level award for student paper, Canadian Biomaterials Society
- Canadian Biomaterials Society, Summer I 1979
- G. Guess Summer Scholarship Award
- Department of Metallurgy and Material Science (MMS), College of Engineering, University of Toronto, Summer I 1976
- Bachlor of Applied Science with Honors
- College of Engineering, University of Toronto, Fall 1973
- Ontario Scholarship for Scholastic Excellence
- Government of Ontario, Canada, Fall 1969
- The Diversity, Equity and Inclusion Award, UA COMT
- College of Medicine Tucson, Summer I 2021
- College of Medicine, Faculty Mentoring Award
- College of Medicine, University of Arizona, Fall 2020
- WAESO URM STEM Outstanding Student Mentorship Career Award
- Western Alliance to Expand Student Opportunities, Spring 2018
- Chair, U.B.R.P. Governing Board
- Undergraduate Biology Research Program, Spring 2017
- Presidential Recognition Letter
- UA President, Spring 2016
- Graduate College Service Recognition Award
- UA Graduate College, Spring 2011
- Likin's Presidential Inclusive Excellence Award
- University of Arizona, Office of the President, Spring 2011
- Bone and Joint Surgeons, Distinguished Service Award
- Association of Bone and Joint Surgeons and Journal of Clinical Orthopaedics and Related Research, Spring 2010
- Outstanding Faculty Mentor Award, UBRP
- Undergraduate Biology Research Program, Fall 2008
- UAC, Investigator of the Year
- UA, University Animal Care, Spring 2005
- Mentor of the Year, Louis Stokes Alliances for Minority Participation (LSAMP), WAESO Chapter
- National Science Foundation/ WAESO, Spring 2003
- William & Sylvia Rubin Chair in Orthopaedic Research
- Arizona Arthritis Center and Orthopaedic Surgery Department, Spring 2003
- Cover Article, Journal Biomedical Materials Research - B
- Journal Biomedical Materials Research - B, Summer I 2000